Rockefeller University Scientists use algorithm to peer through opaque brains

Trying to pinpoint signals from individual neurons within a block of brain tissue is like trying to count headlights in thick fog. A new algorithm, developed by researchers based at The Rockefeller University, brings this brain activity into focus. In research described June 26 in Nature Methods, the team, led by Rockefeller’s Alipasha Vaziri, used a light microscope-based technique to capture neural activity within a volume of mouse brain tissue at unprecedented speed. The algorithm allowed ...
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Augusta University research suggest, age and obesity conspire to damage the tiny blood vessels that feed the heart, causing heart failure

Age and obesity appear to create a perfect storm that can reduce blood flow through the tiny blood vessels that directly feed our heart muscle and put us at risk for heart failure, scientists report. They call it “aged fat” and scientists now have evidence that the inflammation created by both age and fat have an additive effect that can thicken the walls of our coronary microvasculature without any  evidence of  the classic atherosclerotic plaque that many of us associate with heart disease....
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FDA approved gammaCore a non-invasive vagus nerve stimulator from electroCore to treat acute pain

electroCore, a neuroscience and technology company dedicated to improving patient outcomes through technological advancement, announced that the U.S. Food and Drug Administration (FDA) released the use of gammaCore® (non-invasive vagus nerve stimulator) for the acute treatment of pain associated with episodic cluster headache in adult patients. gammaCore transmits a mild electrical stimulation to the vagus nerve through the skin, resulting in a reduction of pain. This is the first FDA product re...
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Sao Paulo Medical journal research suggest, patient mortality rate is Influenced of time elapsed from end of emergency surgery until admission to intensive care unit.

Influence of time elapsed from end of emergency surgery until admission to intensive care unit, on Acute Physiology and Chronic Health Evaluation II (APACHE II) prediction and patient mortality rate The intensive care unit is the part of the hospital that is dedicated to providing a system of continuous surveillance for seriously ill patients who are potentially recoverable or at risk.1 The high-complexity features of these services and their high cost make it difficult to offer enough beds i...
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Patients whose emergency surgery is delayed are at higher risk of death

BACKGROUND: Delay of surgery for hip fracture is associated with increased risk of morbidity and mortality, but the effects of surgical delays on mortality and resource use in the context of other emergency surgeries is poorly described. Our objective was to measure the independent association between delay of emergency surgery and in-hospital mortality, length of stay and costs. METHODS: We identified all adult patients who underwent emergency noncardiac surgery between January 2012 an...
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Neddleless computer controlled drug injection

The Portal drug delivery technology is needle-free, fast and computer-controlled. It automatically adjusts the injection velocity up to one thousand times in the half-second it takes to completely deliver a 1 ml dose. The result is the precise administration of high viscosity biologic drugs through the skin, via an extremely collimated jet, the size of a strand of hair. HIPPA-compliant, automatic collection and transfer of injection and health data sets a new standard of engagement between the c...
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University of Texas researcher have identified how pythons regenerate their organs and other secrets of the snake genome.

Evolution takes eons, but it leaves marks on the genomes of organisms that can be detected with DNA sequencing and analysis. As methods for studying and comparing genetic data improve, scientists are beginning to decode these marks to reconstruct the evolutionary history of species, as well as how variants of genes give rise to unique traits. A research team at the University of Texas at Arlington led by assistant professor of biology Todd Castoe has been exploring the genomes of snakes an...
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Edward Via College of Osteopathic Medicine (VCOM) and Virginia Tech research study finds common household chemicals are responsible for diminished reproduction in mice

Edward Via College of Osteopathic Medicine (VCOM) and Virginia Tech researchers who were using a disinfectant when handling mice have discovered that two active ingredients in it cause declines in mouse reproduction. Although the chemicals responsible for the declines are common in household cleaning products and disinfectants used in medical and food preparation settings, including hand sanitizers, academic scientists have never published a rigorous study, until now, on their safety or toxicity...
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University of Notre Dame have found that exposure to just 10 minutes of light at night suppresses biting and manipulates flight behavior in the Anopheles gambiae mosquito.

Scientists at the University of Notre Dame have found that exposure to just 10 minutes of light at night suppresses biting and manipulates flight behavior in the Anopheles gambiae mosquito, the major vector for transmission of malaria in Africa, according to new research published in the journal Parasites and Vectors. Critical behaviors exhibited by the species, such as feeding, egg laying and flying, are time-of-day specific, including a greater propensity for nighttime biting. A recent repo...
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3D cell culture is an artificially-created environment in which biological cells are permitted to grow or interact with their surroundings in all three dimensions

3D cell culture is an artificially-created environment in which biological cells are permitted to grow or interact with their surroundings in all three dimensions. Unlike 2D environments (e.g. a petri dish), a 3D cell culture allows cells in vitro to grow in all directions, similar to how they would in vivo. These three-dimensional cultures are usually grown in bioreactors, small capsules in which the cells can grow into spheroids, or 3D cell colonies. Approximately 300 spheroids are usually cul...
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UNIVERSITAT ROVIRA research suggest Obesity alters the relationship between a biomarker of iron levels and the incidence of type 2 diabetes

Obesity alters the relationship between a biomarker of iron levels and the incidence of type 2 diabetes The association between levels of a biomarker known as the soluble transferrin receptor (sTfR) and the risk of type 2 diabetes in a population with high cardiovascular risk is conditioned by the presence of absence of obesity Whereas in non-obese people, high levels of the soluble transferrin receptor are associated with a lower risk of developing type 2 diabetes, in obese people t...
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University of Maryland Medical Center research suggest flax seeds provide nutrients and also health benefits to reduce the risk of chronic diseases

Flaxseed is emerging as an important functional food ingredient because of its rich contents of α-linolenic acid (ALA, omega-3 fatty acid), lignans, and fiber. Flaxseed oil, fibers and flax lignans have potential health benefits such as in reduction of cardiovascular disease, atherosclerosis, diabetes, cancer, arthritis, osteoporosis, autoimmune and neurological disorders. Flax protein helps in the prevention and treatment of heart disease and in supporting the immune system. As a functional ...
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‘PolarityTE’ novel regenerative medicine and tissue engineering platform that employs patients’ own cells for the healing of full-thickness functionally-polarized tissues

Functionally Polarized Tissue Polarity is an entirely new and radically unique regenerative medicine company committed to developing the first forms of functionally-polarized autologous tissues for use in medical procedures requiring reconstructive applications by surgeons and wound care specialists. At PolarityTE, revolutionary platform is being developed to induce cell and tissue polarity, creating uniquely functional tissue to mirror natural development in the human body. Using i...
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Radboud University Netherlands research suggest learning to read in your thirties profoundly transforms brain networks

Reading is such a modern cultural invention that, so far, there is no specific area in the human brain dedicated to it. An international team of scientists led by the Max Planck Institute (MPI) for Psycholinguistics in Nijmegen and the MPI for Human Cognitive and Brain Sciences in Leipzig have found that learning to read as an adult reconfigures brain areas hitherto assigned to different skills. Most strikingly, evolutionarily ancient structures - located deep inside the brain - are more fundame...
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3D bioprinting is the process of creating cell patterns in a confined space using 3D printing technologies

3D bioprinting is the process of creating cell patterns in a confined space using 3D printing technologies, where cell function and viability are preserved within the printed construct. Current 3D printing technology has advanced quickly in recent years, enabling people to print 3D models of non-living objects. More recently, researchers in the biomedicine have also begun to use this technology to print human organs and tissues with devices called “3D Bioprinters.” Wake Forest Institute for R...
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Rush University medical Center research suggest, skin color is no shield against melanoma

Sidney Brown thought the mole on his nose was just an annoying pimple. He didn’t consider that it could be a cancerous tumor, because, Brown thought, “skin cancer is something white people get.” The misconception that people with more pigment — called melanin — in their skin cells are protected from cancer-causing ultraviolet rays nearly cost Brown his life. Non-whites have higher melanoma-related mortality rates Brown’s mole turned out to be a melanoma, the least common form of skin cancer...
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Gastrojournal – Prebiotics reduce body fat in children who are overweight or obese by altering their gut microbiota, according to new research

Increasing globally, particularly in children, obesity is a serious public health issue and risk factor for overweight and metabolic disease in later life. Both in experimental animal and human studies, advances in gene sequencing technologies have yielded intriguing possibilities for the role of the gut microbiome in later development of overweight status. Before translating study findings into practice, we must first reconcile inconsistencies between animal experimentation, and human adult and...
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‘ FAU Erlangen-Nürnberg’ has invited open challenge to researchers to submit a walking-visualization-tool of gait sequences based on given inertial sensor-based gait recordings acquired using intelligent engineering technology

What is this challenge about? IMAGINE - Innovative Medical Application on Gait Visualization using Intelligent Engineering The challenge asks researchers to submit a walking-visualization-tool of gait sequences based on given inertial sensor-based gait recordings acquired using intelligent engineering technology, which was developed at FAU Erlangen-Nürnberg. Seeing is believing: Doctors want to see how the patient was walking - even if they cannot see the patient. Your innovative visualiza...
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FDA approved ‘Kiva VCF’ Treatment System provides a new implant-based approach to vertebral augmentation in the treatment of painful VCFs

Compression fractures affect many individuals worldwide. An estimated 1.5 million vertebral compression fractures occur every year in the US. They are common in elderly populations, and 25% of postmenopausal women are affected by a compression fracture during their lifetime. Although these fractures rarely require hospital admission, they have the potential to cause significant disability and morbidity, often causing incapacitating back pain for many months. This review provides information on t...
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Georgia State University have rewired the neural circuit of one species and given it the connections of another species to test a hypothesis about the evolution of neural circuits and behavior.

Scientists at Georgia State University have rewired the neural circuit of one species and given it the connections of another species to test a hypothesis about the evolution of neural circuits and behavior. Neurons are connected to each other to form networks that underlie behaviors. Drs. Akira Sakurai and Paul Katz of Georgia State’s Neuroscience Institute study the brains of sea slugs, more specifically nudibranchs, which have large neurons that form simple circuits and produce simple beha...
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“Targeted drug delivery” growing trend for many chronic medical conditions.

Targeted drug delivery, sometimes called smart drug delivery, is a method of delivering medication to a patient in a manner that increases the concentration of the medication in some parts of the body relative to others. Despite the progress in techniques for cancer prevention, detection, and treatment, as well as for increasing the public awareness in recent years, this disease is projected to become the leading cause of death worldwide. Advancements in omics, analytical procedures, and high t...
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Hong Kong Polytechnic University research on shoe insole helps to improve the performance of plantar pressure reduction and perceived comfort.

Hong Kong Polytechnic University research on shoe insole helps to improve the performance of plantar pressure reduction and perceived comfort. Orthotic insoles are commonly used in the treatment of the diabetic foot to prevent ulcerations. The insoles are normally custom-made to provide an optimum fit and reduce and/or redistribute pressure on different plantar regions. The multi-layered design of the insoles not only accommodates the foot shape and provides comfort, but also maximizes the fu...
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George Mason University’s College of Health and Human Services research suggest, prunes may prevent bone loss in postmenopausal women

If you need yet another reason to increase your intake of nutrient-rich fruits, here’s one. Consuming four to five prunes each day may help prevent bone loss in postmenopausal women, according to a manuscript released this month by Taylor C. Wallace, a professor in George Mason University’s College of Health and Human Services. The beneficial effects of dried plums on bone health could relate to the phenolics, a type of antioxidant, found in fruits, Wallace said. A handful of small clinic...
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UNIVERSITY OF COPENHAGEN research suggest, food is not just the sum of its nutrients. It is time to rethink nutrition labelling

The nutritional value of a food should be evaluated on the basis of the foodstuff as a whole, and not as an effect of the individual nutrients. This is the conclusion of an international expert panel of epidemiologists, physicians, food and nutrition scientists and brought together by the University of Copenhagen and University of Reading. Their conclusion reshapes our understanding of the importance of nutrients and their interaction. Cheese have a lesser effect on blood cholesterol th...
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Augusta University research suggest, pain reliever pentazocine may help relieve the vision damage of glaucoma

The tip of our optic nerve is typically the first place injured by glaucoma. Now researchers want to know if the powerful pain medicine (+)-pentazocine can help avoid the damage. Their focus is star-shaped brain cells called astrocytes that normally nourish and protect the neurons in the eye, called retinal ganglion cells, at the juncture where the optic nerve sends visual information to the brain so we can see. Glaucoma appears to change the relationship between these two brain cell types...
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Platelet Rich Plasma (PRP) is used from healing of injured tendons, ligaments, muscles, joints and hair loss

Platelet-rich plasma (PRP) is a concentrate of platelet-rich plasma protein derived from whole blood, centrifuged to removed red blood cells. It has a greater concentration of growth factors than whole blood, and has been used to encourage a brisk healing response across several specialties, in particular dentistry, orthopedics and dermatology. As a concentrated source of blood plasma and autologous conditioned plasma, PRP contains several different growth factors and other cytokines that can s...
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Researchers may now be able to Diagnose Alzheimer’s Disease Using Saliva’s 1H NMR-Based Metabolomics.

Investigators found salivary molecules hold promise as reliable diagnostic biomarkers. The study exemplifies the quest by scientists to combat Alzheimer’s disease, a degenerative brain disorder with no cure and few reliable diagnostic tests. In the United States, Alzheimer’s is a health epidemic affecting more than 5 million Americans. Investigators seek to develop valid and reliable biomarkers, diagnosing the disease in its earliest stages before brain damage occurs and dementia begins. R...
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NILE Proximal Fixation Spinal System can help overcome complex deformity cases and has now received FDA approval

NILE Proximal Fixation Spinal System helps overcome complex deformity cases by supporting alternative Fixation Spinal System using non-pedicle based fixation technology. NILE Proximal Fixation Spinal System received FDA approval Bone fixation cerclage, acts as a bone anchor for temporary stabilization, or used in conjunction with other medical implants of similar metals when wiring is needed, during development of a spinal fusion. Wrapped around a portion of the sublaminar, posterior sp...
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University of Illinois, researchers have developed a simple, disposable sensor for detecting hazardous uranium ions

Researchers at the University of Illinois at Urbana-Champaign have developed a simple, disposable sensor for detecting hazardous uranium ions, with sensitivity that rivals the performance of much more sophisticated laboratory instruments.   The sensor provides a fast, on-site test for assessing uranium contamination in the environment, and the effectiveness of remediation strategies, said Yi Lu, a chemistry professor at Illinois and senior author of a paper accepted for publication in...
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Rockefeller University have discovered tantalizing clues about the origins of our ability to understand what other people are thinking

Working with rhesus monkeys, researchers have identified a brain network dedicated to processing social interaction. Scientists call our ability to understand another person’s thoughts—to intuit their desires, read their intentions, and predict their behavior—theory of mind. It’s an essential human trait, one that is crucial to effective social interaction. But where did it come from? Working with rhesus macaque monkeys, researchers in Winrich Freiwald’s Laboratory of Neural Systems ...
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