‘PolarityTE’ novel regenerative medicine and tissue engineering platform that employs patients’ own cells for the healing of full-thickness functionally-polarized tissues

Functionally Polarized Tissue

Polarity is an entirely new and radically unique regenerative medicine company committed to developing the first forms of functionally-polarized autologous tissues for use in medical procedures requiring reconstructive applications by surgeons and wound care specialists.

At PolarityTE, revolutionary platform is being developed to induce cell and tissue polarity, creating uniquely functional tissue to mirror natural development in the human body.

Using investigational platform technology to regenerate full-thickness, fully-functional skin in humans with SkinTE. The process being developed should allow a patient’s own skin to be fully expanded from a small biopsy, and then regenerate all layers (epidermis & dermis), hair and appendages – which has never been done before.

PolarityTE develops full-thickness hair-bearing skin for treatment of burns, wounds and scars with launch product SkinTE.

Manufacturing Process

Skin is so much more than just keratinocytes. The largest organ in the human body requires intricate interactions and polarity to function. Recognizing this allows hair follicle/shaft and appendage regeneration.

Recognition of hierarchical tissue allows for nascent hair follicle/shaft development and complete third degree burn wound healing in preclinical models

SkinTE Platform has demonstrated regenerative capacity across a wide spectrum of scaffolds, including readily available and off-the-shelf marketed products, providing ample opportunities for strategic partnerships.

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Regenerative and angiogenic/vasculogenic transcriptomics and proteomics are upregulated in the setting of SkinTE regenerative construct when applied to full-thickness third degree burn wound models. The science and data are robust – it’s time to make SkinTE a clinical reality.

PolarityTE, Inc. is the owner of a novel regenerative medicine and tissue engineering platform developed and patented by Denver Lough MD, PhD. This radical and proprietary technology employs a patients’ own cells for the healing of full-thickness functionally-polarized tissues. If clinically successful, the PolarityTE platform will be able to provide medical professionals with a truly new paradigm in wound healing and reconstructive surgery by utilizing a patient’s own tissue substrates for the regeneration of skin, bone, muscle, cartilage, fat, blood vessels and nerves. It is because PolarityTE uses a natural and biologically sound platform technology, which is readily adaptable to a wide spectrum of organ and tissue systems, that the company and its world-renowned clinical advisory board, are poised to drastically change the field and future of translational regenerative medicine.

Credit:  polarityte.com

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